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KMID : 1120320170030000081
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Osteoporosis and Sarcopenia
2017 Volume.3 No. 0 p.81 ~ p.81
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Interplay of vitamin D, vitamin B12, homocysteine and bone mineral density in postmenopausal females
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Sundus T.
Saba T.
Khalid P.L.
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Abstract
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Objective: Osteoporosis is most common age related, multifactorial disease. The study was designed to find out the association between serum homocysteine (Hcy), vitamin D, vitamin B12 and bone mineral density (BMD) in postmenopausal non-osteoporotic and osteoporotic females.
Materials and methods: In this cross sectional study, 156 postmenopausal females between 50-70 years of age were recruited and divided into two groups, non-osteoporotic (n=52) and osteoporotic (n=104). BMD was measured from phalanges by peripheral ultrasound bone densitometer. Mann-Whitney U test was applied for comparison, spearman's rho correlation was used to establish correlations, while strength of association was seen by multiple regression analysis.
Results: BMD values were significantly different in two groups (-0.51 (-0.74 to -0.62) versus -3.6 (-3.81to-3.44), p < 0.001). There was significant negative correlation of Hcy with vitamin D (r = -0.383, p = 0.005) and B12 (r = -0.430, p = 0.001) in postmenopausal non-osteoporotic and Hcy with vitamin B12 (rho= -0.376, p < 0.001) in postmenopausal osteoporotic females. Serum Hcy levels were predicted by vitamin D in postmenopausal non-osteoporotic and vitamin B12 in postmenopausal osteoporotic females.
Conclusion: The results indicate that serum Hcy levels are associated with vitamin D and B12 while it has no relation with BMD in postmenopausal non-osteoporotic and osteoporotic females. Our results are similar to following studies.
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